Are plant sterols and plant stanols a viable future treatment for dyslipidemia?
نویسندگان
چکیده
منابع مشابه
Serum TG-lowering properties of plant sterols and stanols are associated with decreased hepatic VLDL secretion.
Plant sterols and stanols are structurally similar to cholesterol and when added to the diet they are able to reduce serum total- and LDL-cholesterol concentrations. They also lower serum triglyceride concentrations in humans, particularly under conditions of hypertriglyceridemia. The aim of this study was to unravel the mechanism by which plant sterols and stanols reduce serum triglyceride con...
متن کاملMeta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols versus policosanol.
STUDY OBJECTIVE To compare the efficacy and safety of plant sterols and stanols as well as policosanol in the treatment of coronary heart disease, as measured by a reduction in low-density lipoprotein cholesterol (LDL) levels. DESIGN Systematic review and meta-analysis of randomized controlled trials. PATIENTS A total of 4596 patients from 52 eligible studies. MEASUREMENTS AND MAIN RESULT...
متن کاملComparison of the intestinal uptake of cholesterol, plant sterols, and stanols in mice.
The recent identification of the aberrant transport proteins ABCG5 and ABCG8 resulting in sitosterolemia suggests that intestinal uptake of cholesterol is an unselective process, and that discrimination between cholesterol and plant sterols takes place at the level of sterol efflux from the enterocyte. Although plant sterols are structurally very similar to cholesterol, differing only in their ...
متن کاملPlant sterols/stanols as cholesterol lowering agents: A meta-analysis of randomized controlled trials
BACKGROUND Consumption of plant sterols has been reported to reduce low density lipoprotein (LDL) cholesterol concentrations by 5-15%. Factors that affect plant sterol efficacy are still to be determined. OBJECTIVES To more precisely quantify the effect of plant sterol enriched products on LDL cholesterol concentrations than what is reported previously, and to identify and quantify the effect...
متن کاملPlant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation.
Plant stanols and sterols of the 4-desmethyl family (e.g., sitostanol and sitosterol) effectively decrease LDL cholesterol concentrations, whereas 4,4-dimethylsterols (alpha-amyrin and lupeol) do not. Serum carotenoid concentrations, however, are decreased by both plant sterol families. The exact mechanisms underlying these effects are not known, although effects on micellar composition have be...
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ژورنال
عنوان ژورنال: Expert Review of Cardiovascular Therapy
سال: 2016
ISSN: 1477-9072,1744-8344
DOI: 10.1586/14779072.2016.1166956